Download Page
The criteria for case inclusion/exclusion during an ourbreak will be unique and locally
determined by outbreak control team. Definitions are usually based on clinical features and/or
the results of diagnostic tests and also specify the time and place of the putative exposure.
For previously used exemplar outbreak definitions see here. To
create an outbreak case definition consider the following criteria:
Clinical Criteria: Confirmed radiological or clinical pneumonia
Epidemiological Criteria: Case has visited location common to other cases, in
14 days prior to onset (this might simply be a town or broad geographic area or more focussed
on a particular street or address if/once source is suspected) and
case has onset date within defined window (set by Outbreak Control Team -perhaps over weeks or
months if associated with broad community area or focussed over a few days or weeks if release
is associated with a particular event).
Microbiological Criteria A: Laboratory evidence of at least one of
the following:
- Isolation (culture) of Legionella species from respiratory secretions or any
normally sterile site
- The presence of L. pneumophila urinary antigen determined using validated
reagents/kits
-
L. pneumophila serogroup 1 specific antibody response.
Microbiological Criteria B: Laboratory evidence of at least one of
the following:
- Detection of Legionella pneumophila antigen in respiratory secretions or
lung tissue e.g. by DFA staining using monoclonal-antibody derived reagents
- Detection of Legionella spp. nucleic acid in a clinical specimen
-
L. pneumophila non-serogroup 1 or other Legionella spp. specific antibody
response
-
L. pneumophila serogroup 1, other serogroups or other Legionella species:
single high titre in specific serum antibody.
Then for an outbreak:
A confirmed case should be one that meets clinical, epidemiological
and mircobiological criteria A.
A probable case should be one that meets clinical, epidemiological
and mircobiological criteria B.
In an outbreak, case definitions may vary over the course of investigation as more information
becomes available and will likely become more specific later on. An initially broad case
definition, established at the outset of an investigation, will help identify anyone who might
possibly be a case; it is better to gather too much information than too little. Such changes in
case inclusion criteria should be carefully noted and registered with relevant agencies.
In an ongoing outbreak response, following active case finding and
microbiological matching of environmental source to initial cases, in certain situations the
outbreak control team might find it necessary to simply define a probable case as one that
meets only the clinical and epidemiological criteria above,
see for example the outbreak described by Den Boer et al., 2002.
|